UPDATED July 25,2018 – A Brain injury may be defined as an injury from the brain no matter age at onset. A brain injury can result a substantial handicap to the individual who sustained the brain injury and may trigger numerous types of cognitive impairments like lack of focus, memory or other motor-neurological disorders such as ataxia, ALS, Spinal muscular atrophy or Parkinson’s Disease. A brain injury may also consist of any injury that’s vascular by nature and not traumatic where there was an event that directly caused or instigated the injury.
Modern treatment options for head injuries are usually divided into 2 types. Closed head injuries and penetrating head injuries. Overlap for the 2 types does exist and Closed head injury treatments can be further segmented into mild, moderate, or severe/traumatic head injuries. A brain injury is dissimilar from a traumatic brain injury (TBI) or stroke because an exterior force injures the brain in a damaging violent manner. TBI is an injury in the brain which is brought about by some type of traumatic influence. TBI can be caused by a blows to the head, cranial penetration or even violent tremblings. Depending on the cause and severity of the brain injury, the brain damage can be classified as serious, moderate or mild and damage from neurodegeneration can include,glia cells, neurons, endothelial cells and Axonal Degeneration. (Dharmasaroja 2008)*
Stem Cells to Repair Brain Damage (VDO)
Each region of the human brain and spinal cord possess various types of specialized cells. The Regen Center Neural Cell replacement protocol works through usage of adult neural stem cells, for specific regions that help in the development of the central nervous system (CNS).
The goal of our Neurocell therapy and spinal cord injuries is to target the damaged areas and then to repair or dead, damaged or diseased progenitor cells that are found in the neurogenic regions .
Initial symptoms and signs of the TBI could consist of:
- Headaches
- Blurred vision
- Dizziness
- Confusion
- Seizures
- Memory loss
- Loss of consciousness
- Paralysis
- Coma
How Stem Cells Reverse Damage From Brain Injuries
Brain Stem cells transplantation into the affected region might be beneficial in certain circumstances wherein the damage is not to severe and has occurred relatively recently. (from 6 mo up to two years after initial Injury) The neural stem cellimplantation purpose would be to attempt to restore signal functions with comparable properties. In situations of TBI, numerous cell kinds are required (glial, neuronal, vascular, endothelial and so on) to regenerate the complex functions of largely damaged regions of the brain.(Kunkanjanawan, Noisa, and Parnpai 2011)*
Types of Brain Injuries
The Glasgow Coma Scale (GCS), is currently the most commonly used system around the world for classifying the severity of traumatic brain injuries. The GSCs scale is from 3–15 based on the patients motor, verbal and eye-opening reactions to induced stimuli. Pathological features used to classify TBI include:
- Diffuse axonal injury (DAI)
- Focal brain injury
Neural Cell Replacement Therapy
In much more severe instances of traumatic brain related injuries such as Chronic traumatic encephalopathy (CTE) there are complications that can be fatal. While the rigorousness of the TBI differ broadly, the consequences of it in the long run are frequently devastating and life-changing. TBI are typically very sudden. The physical, non-congenital harm towards the brain by an external force may permanently or temporarily disrupt regular brain function. (Prè et al. 2014)* Brain characteristics and functions that may be affected include temporary or permanent loss of consciousness, speech, language, memory, character, mobility, joint pain with lupus, peripheral neuropathy and recognition of other people. Since the brain controls all bodily functions, any harm towards the brain, no matter how little or severe it is, can impair physical and psychological activity.
TREATMENT PRECAUTION
The Regeneration Center Does Not Accept Patients With Brain and/or Spinal Injuries older than 24 months old. All Neurodegenerative disease treatments will also require physical ability to travel to Bangkok for the 2-3 week protocol.
Treatment Options For Brain Injuries
Number of Cell Injections: 2-8 Infusions of MSC+ cells, Neural Progenitor Cells with fibroblast growth factors, cytokines and chemokines to allow for higher survival rates of transplanted cells per treatment stage.
Type of Injections:
A combination therapy will be required for most brain injuries with the goal of increased recovery of any lost cognitive function Our cell delivery systems are very safe and administered via Stereotactic-guided delivery, inhalation via micro-nebulizer, Intravenous Drip and/or Intrathecally.
Rehabilitation Post-Treatment : Physical Rehabilitation therapy in Bangkok is optional depending on the patients travel/time constraints. Complete physical rehabilitation post-therapy and can be provided upon request for 2-4 hours per day and up to 5 days per week. Medical visas and extended stay accommodations for the patient and family can also be included upon request.
Costs Related to Treating Brain Injuries with Stem Cells & Physical Rehab
Our treatments protocol for Traumatic Brain Injuries will require a minimum of 14-21 nights in Bangkok. Due to the significant differences in brain injury treatment requests our neurological stem cell team will need to qualify the potential candidate for treatment. Upon approval, a detailed treatment plan will be provided that will includes the specifics of the treatment plan that will include: total number nights required along with the total medical related expenses including cell extraction,enrichment and infusions (excluding accommodations or flights). To begin the qualification process for the multi-stage TBI neural stem cell transplants, please prepare your recent medical records such as recent Brain MRI’s,CT Scans or PET Scans (Preferred) and contact us today.
Published Clinical Citations
-
Dharmasaroja, Permphan. 2008. Bone marrow-derived mesenchymal stem cells for the treatment of ischemic stroke. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, no. 1 (November 18). doi:10.1016/j.jocn.2008.05.006. http://www.ncbi.nlm.nih.gov/pubmed/19017556.
-
Kunkanjanawan, Tanut, Parinya Noisa, and Rangsun Parnpai. 2011. Modeling neurological disorders by human induced pluripotent stem cells. Journal of biomedicine & biotechnology (November 24). doi:10.1155/2011/350131. http://www.ncbi.nlm.nih.gov/pubmed/22162635.
-
Prè, Deborah, Michael W Nestor, Andrew A Sproul, Samson Jacob, Peter Koppensteiner, Vorapin Chinchalongporn, Matthew Zimmer, Ai Yamamoto, Scott A Noggle, and Ottavio Arancio. 2014. A time course analysis of the electrophysiological properties of neurons differentiated from human induced pluripotent stem cells (iPSCs). PloS one, no. 7 (July 29). doi:10.1371/journal.pone.0103418. http://www.ncbi.nlm.nih.gov/pubmed/25072157
Don’t wear seat belts lest you drown in you own urine?
With thanks! Valuable information!
Don’t wear seat belts lest you drown in your own urine?